Giving notice at a job you love, for a job you hope will propel your career to new levels

My friend Jacquie Mardell, UCSC-extension Professor and a very accomplished women in the field of Clinical Research writes and mentors a lot of her students using her posts at 2 Decades & Counting I read her posts regularly and her recent post caught my attention as we as a professional have gone through similar situations in our career where we have to give notice at a job we love, for a job we think will take our career to a new level.
She has made very good and practical points in her post, a must read:
http://2decades.blogspot.com/2010/07/more-student-advice.html